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Nb80 binding to the receptor for adrenaline

Steyaert lab

Nanobodies for Structural Biology and Drug Discovery

The Steyaertlab pioneered the use of nanobodies in X-ray crystallography, aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes.

Recent work focusses on exploiting Nanobodies for drug discovery on difficult targets like GPCRs and on the engineering of nanobodies to be used in single particle cryo-EM and OMICs appications.

Jan Steyeart

Jan Steyaert

Science Director

VIB Science Director since 2017
VIB Group leader since start VIB, 1995
VUB Full professor
Postdoc: ILRI, Nairobi, Kenya, 1993-1994
PhD: Vrije Universiteit Brussel, Belgium, 1991